چهارشنبه 24 اردیبهشت 1404
[Archive]
دوره 19، شماره 5 - ( 3-1400 )
جلد 19 شماره 5 صفحات 317-317 |
برگشت به فهرست نسخه ها
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Aghajani Sh, Mehrafza M, Hosseini A, Salehzadeh A, Ghasemiyan F, Eftekhari A, et al . P-150 Analysis of the influence of preimplantation genetic testing for aneuploidy results with maternal age. IJRM 2021; 19 (5) :317-317
URL: http://ijrm.ir/article-1-3060-fa.html
URL: http://ijrm.ir/article-1-3060-fa.html
P-150 Analysis of the influence of preimplantation genetic testing for aneuploidy results with maternal age. International Journal of Reproductive BioMedicine. 1400; 19 (5) :317-317
چکیده: (274 مشاهده)
Background: Assisted reproduction techniques and the preimplantation genetic test for aneuploidies help couples with fertility problems to achieve a healthy live birth worldwide. There is a possible correlation between chromosomal aneuploidy and maternal age.
Objective: Evaluating the effect of maternal age on aneuploidy, blastocyst rate, embryo development, and pregnancy outcomes in patients undergoing frozen embryo transfer.
Materials and Methods: This study included an analysis of X, Y, 13, 18, and 21 chromosomes identified by fluorescence in situ hybridization method in embryos from couples undergoing Assisted reproduction techniques and preimplantation genetic test for aneuploidies. The present study included 277 embryos between February 2018 and June 2020. Women were divided into four age groups: ≤ 35, 36-40, 41-45, and ≥ 45 yr. Primary outcomes were the rate of aneuploidy, blastocyst, and pregnancy. Statistical analyzes were performed using SPSS software version 23 and the data were analyzed using the χ2 test. The p < 0.05 was considered statistically significant.
Results: Significant differences among maternal age groups were found in the chemical pregnancy (p < 0.001) outcomes. The blastocyst rates (p = 0.02), early pregnancy loss (p < 0.001), and clinical pregnancy loss (p < 0.001) were related significantly with maternal age. In females with age > 40 yrs. old, there was no euploid blastocyst. Increasing maternal age significantly increases the rate of aneuploidy in sex chromosomes in frozenthawed embryo transfer and fresh cycles (p < 0.001).
Conclusion: The present study results found a significant relationship between maternal age and embryo aneuploidy, and showed that the increasing female ages and aneuploidy rate is related together. A negative association was found between maternal age and blastocyst rate, chemical pregnancy, clinical pregnancy, ongoing pregnancy, and live birth rates in the couple from Intracytoplasmic sperm injection cycles.
Objective: Evaluating the effect of maternal age on aneuploidy, blastocyst rate, embryo development, and pregnancy outcomes in patients undergoing frozen embryo transfer.
Materials and Methods: This study included an analysis of X, Y, 13, 18, and 21 chromosomes identified by fluorescence in situ hybridization method in embryos from couples undergoing Assisted reproduction techniques and preimplantation genetic test for aneuploidies. The present study included 277 embryos between February 2018 and June 2020. Women were divided into four age groups: ≤ 35, 36-40, 41-45, and ≥ 45 yr. Primary outcomes were the rate of aneuploidy, blastocyst, and pregnancy. Statistical analyzes were performed using SPSS software version 23 and the data were analyzed using the χ2 test. The p < 0.05 was considered statistically significant.
Results: Significant differences among maternal age groups were found in the chemical pregnancy (p < 0.001) outcomes. The blastocyst rates (p = 0.02), early pregnancy loss (p < 0.001), and clinical pregnancy loss (p < 0.001) were related significantly with maternal age. In females with age > 40 yrs. old, there was no euploid blastocyst. Increasing maternal age significantly increases the rate of aneuploidy in sex chromosomes in frozenthawed embryo transfer and fresh cycles (p < 0.001).
Conclusion: The present study results found a significant relationship between maternal age and embryo aneuploidy, and showed that the increasing female ages and aneuploidy rate is related together. A negative association was found between maternal age and blastocyst rate, chemical pregnancy, clinical pregnancy, ongoing pregnancy, and live birth rates in the couple from Intracytoplasmic sperm injection cycles.
نوع مطالعه: Congress Abstract |
| بازنشر اطلاعات | |
 |
این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است. |
