Volume 10, Issue 6 (4-2012)                   IJRM 2012, 10(6): 543-548 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Eftekhar M, Khalili M A, Rahmani E. The efficacy of recombinant versus urinary HCG in ART outcome. IJRM 2012; 10 (6) :543-548
URL: http://ijrm.ir/article-1-329-en.html
The efficacy of recombinant versus urinary HCG in ART outcome
Maryam Eftekhar1 , Mohammad Ali Khalili2 , Elham Rahmani * 3
1- Department of Obstetrics and Gynecology, Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2- Department of Embryology, Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
3- Department of Obstetrics and Gynecology, Bushehr University of Medical Sciences, Bushehr, Iran , rahmani@bpums.ac.ir
Abstract:   (2887 Views)
Background: Human chorionic gonadotropin (HCG) has been used as a replacement for the mid-cycle luteinizing hormone (LH) surge for several years. The recent arrival of recombinant DNA technology has made recombinant HCG (rHCG) accessible.
Objective: To assess efficacy of rHCG compared to urinary HCG (uHCG) for triggering of ovulation and induction of final oocyte maturation in assisted reproductive cycles.
Materials and Methods: 200 patients who were candidate for ICSI were randomly divided in two groups. In group I (rHCG), patients received 250μg of rHCG for final oocyte maturation, and in group II (uHCG) the patients received 10000 IU of uHCG. Measured outcomes were number of retrieved oocyte and mature oocyte, maturation rate of oocyte, fertilization rate and clinical pregnancy rate.
Results: The rates of oocyte maturity were similar in both groups. Fertilization rate was similar in two groups (58.58% in rHCG group versus 60.58% in uHCG group p=0.666). The clinical pregnancy rate per cycle was similar in both group 34.0% in rHCG group versus 39% in uHCG group (p=0.310). Conclusion: We demonstrated that rHCG is as effective as uHCG, when it is used for final oocyte maturation in ICSI cycles. The numbers of retrieved oocyte and maturation rates were similar in both groups; also fertilization and clinical pregnancy rates were similar.
Keywords: Recombinant HCG, Urinary HCG, Assisted reproduction technology, Ovulation, Final follicular maturation.
Full-Text [PDF 266 kb]   (444 Downloads) |   |   Full-Text (HTML)  (309 Views)  
Type of Study: Original Article |
References
1. Farrag A, Costantini A, Manna C, Grimaldi G. Recombinant HCG for triggering ovulation increases the rate of mature oocytes in women treated for ICSI. J Assist Reprod Genet 2008; 25: 461-466. [DOI:10.1007/s10815-008-9262-x]
2. Pierce JG, Parsons TF. Glycoprotein hormones: structure and function. Annu Rev Biochem 1981; 50: 465-495. [DOI:10.1146/annurev.bi.50.070181.002341]
3. Chan CCW, Ng EHY, Tang O, Yeung WSB, Lau EYL, Ho P. A prospective, randomized, double-blind study to compare two doses of recombinant human chorionic gonadotropin in inducing final oocyte maturity and the hormonal profile during the luteal phase. J Clin Endocrinol Metab 2005; 90: 3933-3938. [DOI:10.1210/jc.2004-2169]
4. Aboulghar M, Rizk B. Ovarian stimulation. 1st Ed. New york; Cambridge University Press; 2011.
5. Geugeon A. Regulation of ovarian follicular development in primates: facts and hypothesis. Endocr Rev 1996; 17: 121-155. [DOI:10.1210/edrv-17-2-121]
6. Al-Inany H, Aboulghar M. GnRH antagonist in assisted reproduction: a Cochrane review. Hum Reprod 2002; 17: 874-885. [DOI:10.1093/humrep/17.4.874]
7. Wong P, Qiao J, Ho C, Ramaraju GA, Wiweko B, Takehara Y, et al. Current opinion on use of luteinizing hormone supplementation in assisted reproduction therapy: an Asian perspective. Reprod Biomed Online 2011; 23: 81-90. [DOI:10.1016/j.rbmo.2011.03.023]
8. Itskovitz J, Boldes R, Levron J, Erlik Y, Kahana L, Brandes J. Induction of preovulatory luteinizing hormone surge and prevention of ovarian hyperstimulation syndrome by gonadotropin-releasing hormone agonist. Fertil Steril 1991; 56: 213-220. [DOI:10.1016/S0015-0282(16)54474-4]
9. Lin L, Roberts VJ, Yen S. Expression of human gonadotropin-releasing hormone receptor gene in the placenta and its functional relationship to human chorionic gonadotropin secretion. J Clin Endocrinol Metabol 1995; 80: 580-585.
10. Licht P, Russu V, Wildt L. On the role of human chorionic gonadotropin (hCG) in the embryo-endometrial microenvironment: implications for differentiation and implantation. Semin Reprod Med 2001; 19: 37-47. [DOI:10.1055/s-2001-13909]
11. The European Recombinant Human Chorionic Gonadotrophin Study Group. Induction of final follicular maturation and early luteinization in women undergoing ovulation induction for assisted reproduction treatment-recombinant HCG versus urinary HCG. Hum Reprod 2000; 15: 1446-1451. [DOI:10.1093/humrep/15.7.1446]
12. Lei Z, Mishra S, Zou W, Xu B, Foltz M, Li X, et al. Targeted disruption of luteinizing hormone/human chorionic gonadotropin receptor gene. Mol Endocrinol 2001; 15: 184-200. [DOI:10.1210/mend.15.1.0586]
13. Cole LA. New discoveries on the biology and detection of human chorionic gonadotropin. Reprod Biol Endocrinol 2009; 7: 8. [DOI:10.1186/1477-7827-7-8]
14. Humaidan P, Ejdrup Bredkjær H, Bungum L, Bungum M, Grondahl ML, Westergaard L, et al. GnRH agonist (buserelin) or hCG for ovulation induction in GnRH antagonist IVF/ICSI cycles: a prospective randomized study. Hum Reprod 2005; 20: 1213-1220. [DOI:10.1093/humrep/deh765]
15. Zegers-Hochschild F, Fernandez E, Mackenna A, Fabres C, Altieri E, Lopez T. Endocrinology: The empty follicle syndrome: a pharmaceutical industry syndrome. Human Reprod 1995; 10: 2262-2265. [DOI:10.1093/oxfordjournals.humrep.a136281]
16. Chang P, Kenley S, Burns T, Denton G, Currie K, DeVane G, et al. Recombinant human chorionic gonadotropin (rhCG) in assisted reproductive technology: results of a clinical trial comparing two doses of rhCG (OvidrelR) to urinary hCG (ProfasiR) for induction of final follicular maturation in in vitro fertilization-embryo transfer* 1. Fertil Steril 2001; 76: 67-74. [DOI:10.1016/S0015-0282(01)01851-9]
17. Driscoll GL, Tyler JP, Hangan JT, Fisher PR, Birdsall MA, Knight DC. A prospective, randomized, controlled, double-blind, double-dummy comparison of recombinant and urinary HCG for inducing oocyte maturation and follicular luteinization in ovarian stimulation. Hum Reprod 2000; 15: 1305-1310. [DOI:10.1093/humrep/15.6.1305]
18. Uhler ML, Beltsos AN, Edward Grotjan H, Lederer KJ, Lifchez AS. Age-matched comparison of recombinant and urinary HCG for final follicular maturation. Reprod Biomed Online 2006; 13: 315-320. [DOI:10.1016/S1472-6483(10)61433-2]
19. Al-Inany H, Aboulghar MA, Mansour RT, Proctor M. Recombinant versus urinary gonadotrophins for triggering ovulation in assisted conception. Hum Reprod 2005; 20: 2061-2073. [DOI:10.1093/humrep/dei035]
Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Designed & Developed by : Yektaweb