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Teremmahi Ardestani M, Hadi Nodushan H, Aflatoonian A, Ghasemi N, Sheikhha M H. Case control study of the factor V Leiden and factor II G20210A mutation frequency in women with recurrent pregnancy loss. IJRM 2013; 11 (1) :61-64
URL: http://ijrm.ir/article-1-334-en.html
Case control study of the factor V Leiden and factor II G20210A mutation frequency in women with recurrent pregnancy loss
Majid Teremmahi Ardestani1 , Hossein Hadi Nodushan1 , Abbas Aflatoonian2 , Nasrin Ghasemi * 3, Mohammad Hasan Sheikhha4
1- Department of Immunology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2- Department of Obstetrics and Gynecology, Research and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
3- Department of Medical Genetics, Research and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran , n479g@yahoo.co.uk
4- Department of Medical Genetics, Research and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Abstract:   (2902 Views)
Background: Recurrent pregnancy loss (RPL) caused by various genetic and non-genetic factors. After chromosome abnormality, thrombophilia is one of the most important genetic factors that could cause RPL. Factor V Leiden and factor II G20210A mutation were the most common mutations cause thrombophilia in the world.
Objective: The purpose of this study was to determine the frequency of factor V Leiden and prothrombine gene mutations in women with RPL compared with women who had uneventful pregnancies.
Materials and Methods: This case control study evaluates the frequency of factor V-Leiden and factor II G20210 genotypes in 80 women with two or more pregnancy losses, compared with 80 women without adverse pregnancy outcome. The mutations were assessed by PCR-RFLP.
Results: Frequency of the factor V Leiden among cases was 2.5%, which was higher than controls (1.25%), but the difference was not significant. No factor II G20210 mutation was found among cases and controls.
Conclusion: These data did not confirm that factor V Leiden and factor II G20210 mutation might play a role in recurrent pregnancy loss in Iranian women.
Keywords: Factor V Leiden, Factor II G20210A Mutation, Recurrent Abortion.
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Type of Study: Original Article |
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