Volume 11, Issue 1 (4-2013)                   IJRM 2013, 11(1): 1-10 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Khalili M A, Nottola S A, Shahedi A, Macchiarelli G. Contribution of human oocyte architecture to success of in vitro maturation technology. IJRM 2013; 11 (1) :1-10
URL: http://ijrm.ir/article-1-344-en.html
Contribution of human oocyte architecture to success of in vitro maturation technology
Mohammad Ali Khalili * 1, Stefania A Nottola2 , Abbas Shahedi3 , Guido Macchiarelli4
1- Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran , Khalili59@hotmail.com
2- Department of Anatomy, Histology, Forensic Medicine and Orthopaedics, La Sapienza University, Rome, Italy
3- Department of Anatomy, Yazd Branch, Islamic Azad University, Yazd, Iran
4- Department of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, Italy
Abstract:   (3539 Views)
The use of ovarian stimulation for infertility treatment is associated with side effects of ovarian hyperstimulation syndrome (OHSS) and potential cancer risk. This is also true in high risk women such as those polycystic with ovary (PCO) and polycystic ovarian syndrome (PCOS). In vitro maturation (IVM) of oocytes was primarily developed to make IVF safe for women with PCO and at high risk of OHSS. The application of IVM of oocytes to assist clinical infertility treatment remains poor because of the reduced developmental competence of oocytes after IVM, despite several decades of research. Reduced meiotic maturation and fertilization rates, as well as low blastocyst production reveal short-term developmental insufficiency of oocytes when compared with in vivo-matured counterparts. In this review, the structural role of human oocytes, revealed by different technical approaches, to the success of IVM technology is highlighted.
Keywords: Human, Oocyte, In Vitro Oocyte Maturation Technique, Cell Morphology, Ultrastructure.
Full-Text [PDF 763 kb]   (752 Downloads) |   |   Full-Text (HTML)  (629 Views)  
Type of Study: Original Article |
References
1. Ben-Ami I, Komsky A, Bern O, kasterstein E, Komarovsky D, Ron-El R. In vitro maturation of human germinal vesicle-stage oocytes: role of epidermal growth factor-like growth factors in the culture medium. Hum Reprod 2011; 26: 76-81. [DOI:10.1093/humrep/deq290]
2. Liu S, Jing JJ, Feng HL, Ma SY, Li M, Li Y. Evaluation of the immature human oocytes from unstimulated cycles in polycystic ovary syndrome patients using a novel scoring system. Fertil Steril 2010; 93: 2202-2209. [DOI:10.1016/j.fertnstert.2009.01.062]
3. Al-hasani S, Ozmen B, Koutlaki N, Schoepper B, Diedrich K, Schultze-mosgau A. three years of routine vitrification of human zygotes: is it still fair to advocate slow-rate freezing? Reprod Biomed Online 2007; 14: 288-293.
4. Zhao JZ, Zhou W, Zhang W, Ge HS, Huang XF, Lin JJ. In vitro maturation and fertilization of oocytes from unstimulated ovaries in infertile women with polycystic ovary syndrome. Fertil Steril 2009; 91: 2568-2571. [DOI:10.1016/j.fertnstert.2008.03.059]
5. Banwell KM, Thompson JG. In Vitro Maturation of Mammalian Oocytes: Outcomes and Consequences. Semin Reprod Med 2008; 26: 162-174. [DOI:10.1055/s-2008-1042955]
6. Son WY, Tan SL. Laboratory and embryological aspects of hCGprimed in vitro maturation cycles for patients with polycystic ovaries. Hum Reprod Updat 2010; 16: 675-689. [DOI:10.1093/humupd/dmq014]
7. De Vos M, Ortega-Hrepich C, Albuz FK, Guzman L, Polyzos NP, Smitz J, et al. Clinical outcome of non-hCG-primed oocyte in vitro maturation treatment in patients with polycystic ovaries and polycystic ovary syndrome. Fertil Steril 2011; 96: 860-864. [DOI:10.1016/j.fertnstert.2011.07.1108]
8. Eftekhar M, Khalili MA, Aflatoonian A, Esfandiari N. Successful pregnancy following a novel endometrial preparation in a PCOS patient undergoing IVM: a case report. J Assist Reprod Genet 2012; 29: 335-336. [DOI:10.1007/s10815-012-9723-0]
9. Brackett BG, Zuelke KA. Analysis of factors involved in the in vitro production of bovine embryos. Theriogenology 1993; 39: 43-64. [DOI:10.1016/0093-691X(93)90023-X]
10. Bevers MM, Dieleman SJ, Van Den Hurk R, Izadyar F. Regulation and Modulation of oocyte maturation in the bovine. Theriogenology 1997; 47: 13-22. [DOI:10.1016/S0093-691X(96)00335-4]
11. Rose-Hellekant TA, Libersky-Williamson EA, Bavister BD. Energy substrates and amino acids provided during in vitro maturation of bovine oocytes alter acquisition of developmental competence. Zygote 1998; 6: 285-294. [DOI:10.1017/S0967199498000239]
12. Chung JT, Tan SL, Chian RC. Effect of glucose on bovine oocyte maturation and subsequent fertilization and early embryonic development in vitro. Biol Reprod 2002; 66 (Suppl.): 177.
13. Chian RC, Tan SL. Maturational and developmental competence of cumulus-free immature human oocytes derived from stimulated and intracytoplasmic sperm injection cycles. Reprod BioMed Online 2002; 5: 125-132. [DOI:10.1016/S1472-6483(10)61614-8]
14. Thibault C, Gerard M, Menezo Y. Preovulatory and ovulatory mechanisms in oocyte maturation. J Reprod Fertil 1975; 45: 605-610. [DOI:10.1530/jrf.0.0450605]
15. Khalili MA, Mojibian M, Sultan AM. Role of oocyte morphology on fertilization and embryo formation in assisted reproductive techniques. MEFSJ 2005; 10: 72-77.
16. Duranthon V, Renard JP. The developmental competence of mammalian oocytes: a convenient but biologically fuzzy concept. Theriogenology 2001; 55: 1277-1289. [DOI:10.1016/S0093-691X(01)00482-4]
17. Gardner DK, Sheehan CB, Rienzi L, Katz-Jafee M, Larman MG. Analysis of oocyte physiology to improve cryopreservation procedures. Theriogenology 2007; 67: 64-72. [DOI:10.1016/j.theriogenology.2006.09.012]
18. Swain JE, Pool TB. ART failure: oocyte contributions to unsuccessful fertilization. Hum Reprod Update 2008; 14: 431-446. [DOI:10.1093/humupd/dmn025]
19. Pincus G. Ovum culture. Science 1939; 89: 509. [DOI:10.1126/science.89.2318.509]
20. Edwards RG. Maturation in vitro of mouse, sheep, cow, pig,rhesus monkey and human ovarian oocytes. Nature 1965; 208: 349-351. [DOI:10.1038/208349a0]
21. Tsafriri A, Pomerantz SH. Oocyte maturation inhibitor. Clin Endocrinol Metab 1986; 15: 157-170. [DOI:10.1016/S0300-595X(86)80047-0]
22. Downs SM, Eppig JJ. Cyclic adenosine monophosphate and Ovarian Follicular fluid act synergistically to inhibit mouse oocyte maturation. Endocrinolog 1984; 114: 418-427. [DOI:10.1210/endo-114-2-418]
23. Zhang M, Su YQ, Sugiura K, Xia G, Eppig JJ. Granulosa cell ligand NPPC and its receptor NPR2 maintain meiotic arrest in mouse oocytes. Science 2010; 330: 366-369. [DOI:10.1126/science.1193573]
24. Sirard MA, Richard F, Blondin P, Robert C. Contribution of the oocyte to embryo quality. Theriogenology 2006; 65: 126-136. [DOI:10.1016/j.theriogenology.2005.09.020]
25. Kastrop PM, Bevers MM, Destree OH, Kruip TA. Protein synthesis and phosphorylation patterns of bovine oocytes maturing in vivo. Mol Reprod Dev 1991; 29: 271-275. [DOI:10.1002/mrd.1080290309]
26. De Sousa PA, Caveney A, Westhusin ME, Watson AJ. Temporal patterns of embryonic gene expression and their dependence on oogenetic factors. Theriogenology 1998; 49: 115-128. [DOI:10.1016/S0093-691X(97)00406-8]
27. Trimarchi JR, Keefe DL. Assessing the quality of oocytes derived from in vitro maturation: are we looking under the lamppost? Fertil Steril 2006; 85: 839-840.
28. Sun QY, Wu GM, Lai L, Park KW, Cabot R, Cheong HT, et al. Translocation of active mitochondria during pig oocyte maturation, Fertilization and early embryo development in vitro. Reprod 2001; 122: 155-163. [DOI:10.1530/rep.0.1220155]
29. Combelles CM, Cekleniak NA, Racowsky C, Albertini DF. Assessment of Nuclear and cytoplasmic maturation in in vitro matured human oocytes. Hum Reprod 2002; 17: 1006-1016. [DOI:10.1093/humrep/17.4.1006]
30. Cha KY, Chian RC. Maturation in vitro of immature human Oocytes for clinical use. Hum Reprod Update 1998; 4: 103-120. [DOI:10.1093/humupd/4.2.103]
31. Kim BK, Lee SC, Kim KJ, Han CH, Kim JH. In vitro maturation, fertilization and development of human germinal vesicle oocytes collected from stimulated cycles. Fertil steril 2000; 74: 1153-1158. [DOI:10.1016/S0015-0282(00)01617-4]
32. Nazari S, Khalili M, Esmaielzadeh F, Mohsenzadeh M. Maturation capacity, morphology and morphometric assessments of human immature oocytes after vitrification and in vitro maturation. Iran J Reprod Med 2011; 9: 33-37.
33. Mohsenzadeh M, Khalili M, Nazari S, Hemayat-Khah Jahromi V, Agharahimi A, Halvaei I. Effect of vitrification on morphology and in vitro maturation outcome of human immature oocytes. Ital J Anat Embro 2012; 117: 190-198.
34. Child TJ, Abdul-Jalil AK, Gulekli B, Tan SL. In vitro maturation and fertilization of oocytes from unstimulated normal ovaries, polycystic ovaries, and women with polycystic ovary syndrome. Fertil steril 2001; 76: 936-942. [DOI:10.1016/S0015-0282(01)02853-9]
35. Chian RC, Buckett WM, Tan SL. In vitro maturation of human oocytes. Reprod Biomed Online 2004; 8: 148-166. [DOI:10.1016/S1472-6483(10)60511-1]
36. Tan SL, Child TJ. In vitro maturation of oocytes from Unstimulate polycystic ovaries. Reprod Biomed Online 2001; 4 (Suppl.):18-23.
37. Cavilla JL, Kennedy CR, Baltsen M, Klentzeris LD, Byskov AG, Hartshorne GM. The effects of meiosis activating sterol on in vitro maturation and fertilization of human oocytes from stimulated and unstimulated ovaries. Hum Reprod 2001; 16: 547-555. [DOI:10.1093/humrep/16.3.547]
38. Durinzi KL, Saniga EM, Lanzerdorf SE. The relationship between size and maturation in vitro in the unstimulated human oocyte. Fertil Steril 1995; 63: 404-406. [DOI:10.1016/S0015-0282(16)57377-4]
39. Cavilla JL, Kenedy CR, Byskov AG, Hartshorne GM. Human immature oocytes grow during culture for IVM. Hum Reprod 2008; 23: 37-45. [DOI:10.1093/humrep/dem178]
40. Gougeon A. Dynamics of follicular growth in the human: a model from preliminary results. Hum Reprod 1986; 1: 81-87. [DOI:10.1093/oxfordjournals.humrep.a136365]
41. Veeck LL. Abnormal morphology of the human oocyte and conceptus. In: An atlas of human gametes and conceptuses. Carnforth, Lancashire, United Kindom: Parthenon, 1999: 57-68.
42. Ubaldi F, Rienzi L. morphological selection of gamets. Placenta 2008; 29 (Suppl.): 115-120.
43. Krisher RL. The effect of oocyte quality on development. J Anim Sci 2004; 82: 14-23.
44. Gardner DK, Pool TB, Lane M. Embryo nutrition and Energy metabolism and its relationship to embryo growth, Development and viability. Semin Reprod Med 2000; 18: 205-218. [DOI:10.1055/s-2000-12559]
45. Khalili MA, Palmerini MG, Bianchi S, Maione M, Macchiarelli G, Nottola SA. Ultrastructure of human mature oocytes after Vitrification. Eur J Histochem 2012; 56: 236-242. [DOI:10.4081/ejh.2012.e38]
46. Zhao J, Taverne MA, Van der Weijden GC, Bevers MM, Van den Hurk R. Effect of activin A on in vitro development of rat preantral follicles and localization of activin A and activin receptor II. Biol Reprod 2001; 65: 967-977. [DOI:10.1095/biolreprod65.3.967]
47. Raz Ah, Fisch B, Okon E, Feldberg D, Nitke S, Raanani H, Abir R. Possible direct cytotoxicity effects of cyclophosphamide on cultured human follicles: An electron microscopy study. J Assist Reprod Genet 2002; 19: 500-506. [DOI:10.1023/A:1020318704960]
48. Shahedi A, Hoseini A, Khalili MA, Norouzian M, Salehi M, Piraei, et al. The effect of vitrification on ultrastructure of human in vitro matured germinal vesicle oocytes. Eur J Obstet Gynecol Reprod Biol 2012 (in press).
49. Tilly JL. Apoptosis and ovarian function. Rev Reprod 1996; 1: 162-172. [DOI:10.1530/ror.0.0010162]
50. Biron-Shental T, Fisch B, Van Den Hurk R, Felz C, Feldberg D, Abir R. survival of frozen-thawed human ovarian fetal follicles in long- term organ culture. Fertil Steril 2004; 81: 716-719. [DOI:10.1016/j.fertnstert.2003.06.034]
51. Wandji SA, Srsen V, Nathanielsz PW, Eppig JJ, Fortune JE. Initiation of growth of baboon primordial follicles in vitro. Hum Reprod 1997; 12: 1993-2001. [DOI:10.1093/humrep/12.9.1993]
52. Miyara F, Migne C, Dumont-Hassan M, Le Meur A,Cohen-Bacrie P, Aubriot FX, et al. Chromatin configuration and transcriptional control in human and mouse oocytes. Mol Reprod Dev 2003; 64: 458-470. [DOI:10.1002/mrd.10233]
53. Albertini DF, Sanfins A, Combelles CM. Origins and manifestations of oocyte maturation competencies. Reprod Biomed Online 2003; 6: 410-415. [DOI:10.1016/S1472-6483(10)62159-1]
54. Escrich L, Grau N, Meseguer M, Pellicer A, Escriba MJ. Morphologic indicators predict the stage of chromatin condensation of human germinal vesicle oocytes recovered from stimulated cycles. Fertil Steril 2010; 93: 2557-2564. [DOI:10.1016/j.fertnstert.2009.05.077]
55. Zhang X, Li XH, Ma X, Wang ZH, Lu s, Guo YL. Redox-induced apoptosis of human oocytes in resting follicles in vitro. J Soc Gynecol Investig 2006; 13: 451-458. [DOI:10.1016/j.jsgi.2006.05.005]
56. Coticchio G, Sciajno R, Hutt K, Bromfield J, Borini A, Albertini DF. Comparative analysis of the metaphase II spindle of human oocytes through polarized light and high-performance confocal microscopy. Fertil Steril 2010; 93: 2056-2064. [DOI:10.1016/j.fertnstert.2008.12.011]
57. Volarcik K, Sheean L, Goldfarb J, Woods L, Abdul-Karim FW, Hunt P. The meiotic competence of in vitro matured human oocytes is influenced by donor age: evidence that folliculogenesis is compromised in the reproductively aged ovary. Hum Reprod 1998; 13: 154-160.
Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Designed & Developed by : Yektaweb