دوره 11، شماره 9 - ( 9-1392 )                   جلد 11 شماره 9 صفحات 0-711 | برگشت به فهرست نسخه ها

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Walvekar M, Shaikh N, Sarvalkar P. Effects of glycowithanolides on lipid peroxidation and lipofuscinogenesis in male reproductive organs of mice. IJRM 2013; 11 (9) :711-0
URL: http://ijrm.ir/article-1-468-fa.html
اثرات glycowithanolides بر پراکسیداسیون لیپید و lipofuscinogenesis در ارگان های تولیدمثلی موش. International Journal of Reproductive BioMedicine. 1392; 11 (9) :711-0

URL: http://ijrm.ir/article-1-468-fa.html


چکیده:   (2444 مشاهده)
مقدمه: Glycowithanolides (Withaferin A) یکی از موارد اصلی و فعال ویتانولید جدا شده از گیاه Withania somnifera می­باشد و گفته شده که خاصیت aphrodisiac، مسکن، جوان­کننده و طولانی­کننده عمر دارد.
هدف: در مطالعه حاضر خاصیت آنتی اکسیدان موارد اصلی Withania somnifera بر ضد استرس اکسیداتیو تولیدشده به­وسیله D-galactose در بیضه، اپی دیدیم و سمینال وزیکول موش تست شد.
مواد و روش­ها: برای مطالعه حاضر موش­های نر سفید سوییسی (Linn) استفاده شد. آن­ها به گروه­های 1) کنترل، 2) D-galactose، 3) حفاظت شده و 4) درمان شده تقسیم شدند. استرس اکسیداتیو در موش­های 6 ماهه به وسیله دوز پایین D-galactose ایجاد شد. خاصیت ضداکسیدانی عصاره گیاه در بیضه، اپیدیدیم و سمینال وزیکول موش­های استرس داده شده به وسیله لیپید پراکسید (LPO) و محصولات فلورسنت بررسی شد.
نتایج: در مطالعه حاضر هم لیپید پراکسید و محصولات فلورسنت میتوکندریایی و کامل در بیضه، اپیدیدیم و سمینال وزیکول در موش­های تحت درمان با       D-galactose افزایش یافت. بعد از درمان با glycowithanolides به میزان معنی­داری کاهش در لیپیدپراکسید و محصولات فلورسنت میتوکندریایی و کلی در گروه­های حفاظت شده درمان شده دیده شد.
نتیجه­گیری: نتایج ما نشان داد که Withania somniferaتوانایی حفاظت در مقابل استرس اکسسیداتیو را دارا بوده و می­تواند با ناباروری ایجاد شده بر اثر استرس مقابله کند.
 
نوع مطالعه: Original Article |

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