Volume 13, Issue 1 (1-2015)                   IJRM 2015, 13(1): 35-40 | Back to browse issues page

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Li D, Cheng J, Li W, Ma W, Zhou X, Zheng L et al . Association between male infertility and either the +331G/A or the progins polymorphism of the progesterone receptor gene in a Chinese population. IJRM 2015; 13 (1) :35-40
URL: http://ijrm.ir/article-1-589-en.html
Association between male infertility and either the +331G/A or the progins polymorphism of the progesterone receptor gene in a Chinese population
Dandan Li1 , Junjie Cheng1 , Wanghong Li2 , Wei Ma3 , Xu Zhou2 , Lianwen Zheng * 4, Chunjin Li2
1- The Second Hospital of Jilin University, Reproductive Medical Center, Changchun, Jilin Province, 130062, China
2- College of Animal Sciences, Jilin University, 5333 Xi’an Avenue, Changchun, Jilin Province, 130062, China
3- College of Animal Science and Veterinary Medicine, Liaoning Medical University, Jinzhou, Liaoning, China
4- The Second Hospital of Jilin University, Reproductive Medical Center, Changchun, Jilin Province, 130062, China , davezheng@sohu.com
Abstract:   (2593 Views)
Background: Progesterone has been suggested to contribute to the regulation of spermatogenesis and to facilitate the production of viable sperm. Investigations have showed that polymorphism of progesterone receptor (PGR) is associated with some diseases.
Objective: To analyze the potential relationship between male infertility and the +331G/A and progins polymorphisms of PGR gene.
Materials and Methods: The cross-sectional study was carried out at the Department of Male Reproduction, Reproductive Medical Center, the Second Hospital of Jilin University. The restriction fragment length polymorphism (RFLP) technique was used to detect gene point mutations. Of the 145 semen samples analyzed, 35 were asthenozoospermic, 50 were oligoasthenozoospermic, 21 were azoospermic, 11 were teratozoospermic and 28 were from fertile male subjects.
Results: Statistical analyses revealed that the genotypes of the +331G/A polymorphisms were in Hardy-Weinberg equilibrium in both the fertile (χ2=0, p=0.534) and oligospermic groups (χ2=0.021, p=0.537). Similarly, the genotypes of the progins polymorphisms were also in Hardy–Weinberg equilibrium in both the fertile (χ2=0, p=1) and oligospermic groups (χ2=0.005, p=1).
Conclusion: Our results indicated that polymorphisms of the +331G/A and progins of the PGR gene are unrelated to male infertility, at least in a Chinese population.
Keywords: Progesterone receptor, +331G/A polymorphism, Progins polymorphism, Male infertility.
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Type of Study: Original Article |
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