یکشنبه 2 دی 1403
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دوره 14، شماره 4 - ( 1-1395 )
جلد 14 شماره 4 صفحات 240-231 |
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Sabeti P, Pourmasumi S, Rahiminia T, Akyash F, Talebi A R. Etiologies of sperm oxidative stress. IJRM 2016; 14 (4) :231-240
URL: http://ijrm.ir/article-1-745-fa.html
URL: http://ijrm.ir/article-1-745-fa.html
ثابتی پروین، پورمعصومی سهیلا، رحیمی نیا طاهره، اکیاش فاطمه، طالبی علیرضا. اتیولوژی استرس اکسیداتیو بر اسپرم. International Journal of Reproductive BioMedicine. 1395; 14 (4) :231-240
پروین ثابتی1 
، سهیلا پورمعصومی1 ، طاهره رحیمی نیا1 ، فاطمه اکیاش1 ، علیرضا طالبی* 2
، سهیلا پورمعصومی1 ، طاهره رحیمی نیا1 ، فاطمه اکیاش1 ، علیرضا طالبی* 2
1- مرکز تحقیقاتی و درمانی ناباروری، دانشگاه علوم پزشکی شهید صدوقی، یزد ،ایران
2- مرکز تحقیقاتی و درمانی ناباروری، دانشگاه علوم پزشکی شهید صدوقی، یزد ،ایران ،prof_talebi@ssu.ac.ir
2- مرکز تحقیقاتی و درمانی ناباروری، دانشگاه علوم پزشکی شهید صدوقی، یزد ،ایران ،
چکیده: (4177 مشاهده)
اسپرم در مراحل مختلف اسپرماتوژنز نسبت به گونههای فعال اکسیژن (ROS) آسییب پذیر است. با این حال، سطح ROS سیمن توسط آنتی اکسیدانها که اثرات مفیدی بر روی پارامترها و پتانسیل باروری اسپرم دارند، کنترل شده است. میتوکندری و غشای پلاسمایی اسپرم دو محل اصلی تولید ROS در این سلولها می باشند. علاوه بر این، لکوسیتها شامل پلیمورفونوکلوئرها (PMN) و ماکروفاژها، تولید دسته گسترده ای از مولکولهای اکسیژن از جمله رادیکالهای آزاد، گونههای غیررادیکال و گونههای نیتروژن فعال را به عهده دارند. نقش فیزیولوژیکیROS ، افزایش cAMP داخل سلولی و پس از آن فعالسازی پروتئین کیناز در سیستم تناسلی مرد است که نشان میدهد اسپرم به مقدار کمی ازROS ، برای به دست آوردن توانایی و تنظیم بلوغ و تراکم هستهای جهت بارور نمودن تخمک نیاز دارد. عوامل درونی و بیرونی متعددی است که میتواند در تعامل با لیپیدها و پروتئین به ایجاد استرس اکسیداتیو و تولید ROS بیانجامد که نتیجه آن، پراکسیداسیون لیپیدی، قطعه قطعه شدن DNA، آسیب آکسونم، دناتوره شدن آنزیمها، افزایش یون سوپراکساید در میتوکندری، کاهش فعالیت آنتی اکسیدانی و در نهایت اختلال در روند اسپرماتوژنز خواهد بود. به طور کلی علل تولید استرس اکسیداتیو شامل طیف گسترده ای از عوامل بالینی و زیست محیطی میباشد. اگر استرس اکسیداتیو به عنوان عامل اصلی آسیب به DNA در اسپرم پذیرفته شود، پس باید دلیل خوبی برای درمان آنتی اکسیدانی در این شرایط وجود داشته باشد.
نوع مطالعه: Original Article |
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