International Journal of
Reproductive Biomedicine
Sun, Dec 22, 2024
[Archive]
Volume 15, Issue 7 (8-2017)
IJRM 2017, 15(7): 441-446 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Davar R, Naghshineh E, Neghab N. The effect of 24 hours delay in oocyte maturation triggering in IVF/ICSI cycles with antagonist protocol and not-elevated progesterone: A randomized control trial. IJRM 2017; 15 (7) :441-446
URL: http://ijrm.ir/article-1-838-en.html
URL: http://ijrm.ir/article-1-838-en.html
1- Research and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2- Department of Obstetrics and Gynecology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran ,naghshineh@med.mui.ac.ir
2- Department of Obstetrics and Gynecology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran ,
Abstract: (3195 Views)
Background: The best time of final oocyte maturation triggering in assisted reproduction technology protocols is unknown. This time always estimated by combined follicular size and blood progesterone level.
Objective: The aim of this study was evaluation of the effect of delaying oocyte maturation triggering by 24 hr on the number of mature oocytes (MII) and other in vitro fertilization cycle characteristics in antagonist protocols with not-elevated progesterone (p ≤1 ng/ml).
Materials and Methods: All patients' candidate for assisted reproduction technology underwent controlled ovarian hyperstimulation by antagonist protocol. When at least 3 follicles with ≥18 mm diameters were seen by vaginal ultrasonography; blood progesterone level was measured. The patients who had progesterone level ≤1 ng/dl entered the study. The participants' randomizations were done and patients were divided into two groups. In the first group, final oocyte maturation was done by human chorionic gonadotropin at the same day, but in the second group, this was performed 24 hr later. Oocytes retrieval was done 36 hr after human chorionic gonadotropin trigger by transvaginal ultrasound guide.
Results: Number of retrieved oocytes, mature oocytes (MII), fertilized oocytes (2PN), embryos formation, number of transferred embryos and embryos quality has not significant differences between two groups. Also, fertilization and implantation rate, chemical and clinical pregnancy did not differ between groups.
Conclusion: Delaying of triggering oocyte maturation by 24 hr in antagonist protocol with not-elevated progesterone (progesterone ≤1 ng/ml) have not beneficial nor harmful effect on the number of mature oocytes (MII) and other in vitro fertilization cycle characteristics.
Objective: The aim of this study was evaluation of the effect of delaying oocyte maturation triggering by 24 hr on the number of mature oocytes (MII) and other in vitro fertilization cycle characteristics in antagonist protocols with not-elevated progesterone (p ≤1 ng/ml).
Materials and Methods: All patients' candidate for assisted reproduction technology underwent controlled ovarian hyperstimulation by antagonist protocol. When at least 3 follicles with ≥18 mm diameters were seen by vaginal ultrasonography; blood progesterone level was measured. The patients who had progesterone level ≤1 ng/dl entered the study. The participants' randomizations were done and patients were divided into two groups. In the first group, final oocyte maturation was done by human chorionic gonadotropin at the same day, but in the second group, this was performed 24 hr later. Oocytes retrieval was done 36 hr after human chorionic gonadotropin trigger by transvaginal ultrasound guide.
Results: Number of retrieved oocytes, mature oocytes (MII), fertilized oocytes (2PN), embryos formation, number of transferred embryos and embryos quality has not significant differences between two groups. Also, fertilization and implantation rate, chemical and clinical pregnancy did not differ between groups.
Conclusion: Delaying of triggering oocyte maturation by 24 hr in antagonist protocol with not-elevated progesterone (progesterone ≤1 ng/ml) have not beneficial nor harmful effect on the number of mature oocytes (MII) and other in vitro fertilization cycle characteristics.
Type of Study: Original Article |
References
1. Al-Azemi M, Kyrou D, Kolibianakis E, Humaidan P, Van Vaerenbergh I, Devroey P, et al. Elevated progesterone during ovarian stimulation for IVF. Reprod Biomed Online 2012; 24: 381-388. [DOI:10.1016/j.rbmo.2012.01.010]
2. Hu X, Luo Y, Huang K, Li Y, Xu Y, Zhou C, et al. New Perspectives on Criteria for the Determination of HCG Trigger Timing in GnRH Antagonist Cycles. Medicine 2016; 95: e3691. [DOI:10.1097/MD.0000000000003691]
3. Kyrou D, Al-Azemi M, Papanikolaou E, Donoso P, Tziomalos K, Devroey P, et al. The relationship of premature progesterone rise with serum estradiol levels and number of follicles in GnRH antagonist/recombinant FSH-stimulated cycles. Eur J Obstet Gynecol Reprod Biol 2012; 162: 165-168. [DOI:10.1016/j.ejogrb.2012.02.025]
4. Aflatoonian A, Davar R, Hojjat F. Elevated serum progesterone/MII oocyte ratio on the day of human chorionic gonadotropin administration can predict impaired endometrial receptivity. Iran J Reprod Med 2014; 12: 427.
5. Vandekerckhove F, De Baerdemaeker A, Gerris J, Tilleman K, Vansteelandt S, De Sutter P. A randomized controlled trial to evaluate the effect on oocyte yield of prolongating the follicular phase in IVF/ICSI cycles with not-elevated progesterone. Hum Reprod 2013; 28 (Suppl.): i311-i356.
6. Van Vaerenbergh I, Fatemi H, Blockeel C, Van Lommel L, Schuit F, Kolibianakis E, et al. Progesterone rise on HCG day in GnRH antagonist/rFSH stimulated cycles affects endometrial gene expression. Reprod Biomed Online 2011; 22: 263-271. [DOI:10.1016/j.rbmo.2010.11.002]
7. Bosch E, Labarta E, Crespo J, Simon C, Remohi J, Jenkins J, et al. Circulating progesterone levels and ongoing pregnancy rates in controlled ovarian stimulation cycles for in vitro fertilization: analysis of over 4000 cycles. Hum Reprod 2010; 25: 2092-2100. [DOI:10.1093/humrep/deq125]
8. Labarta E, Martínez-Conejero J, Alamá P, Horcajadas J, Pellicer A, Simón C, et al. Endometrial receptivity is affected in women with high circulating progesterone levels at the end of the follicular phase: a functional genomics analysis. Hum Reprod 2011; 26: 1813-1825. [DOI:10.1093/humrep/der126]
9. Papanikolaou E, Pados G, Grimbizis G, Bili E, Kyriazi L, Polyzos N, et al. GnRH-agonist versus GnRH-antagonist IVF cycles: is the reproductive outcome affected by the incidence of progesterone elevation on the day of HCG triggering? A randomized prospective study. Hum Reprod 2012; 27: 1822-1828. [DOI:10.1093/humrep/des066]
10. Vandekerckhove F, Gerris J, Vansteelandt S, De Baerdemaeker A, Tilleman K, De Sutter P. Delaying the oocyte maturation trigger by one day leads to a higher metaphase II oocyte yield in IVF/ICSI: a randomised controlled trial. Reprod Biol Endocrinol 2014; 12: 31. [DOI:10.1186/1477-7827-12-31]
11. Tremellen K, Lane M. Avoidance of weekend oocyte retrievals during GnRH antagonist treatment by simple advancement or delay of hCG administration does not adversely affect IVF live birth outcomes. Hum Reprod 2010: 25: 1219-1224. [DOI:10.1093/humrep/deq059]
12. Kolibianakis EM, Bourgain C, Papanikolaou EG, Camus M, Tournaye H, Van Steirteghem AC, et al. Prolongation of follicular phase by delaying hCG administration results in a higher incidence of endometrial advancement on the day of oocyte retrieval in GnRH antagonist cycles. Hum Reprod 2005; 20: 2453-2456. [DOI:10.1093/humrep/dei069]
13. Venetis C, Kolibianakis E, Papanikolaou E, Bontis J, Devroey P, Tarlatzis B. Is progesterone elevation on the day of human chorionic gonadotrophin administration associated with the probability of pregnancy in in vitro fertilization? A systematic review and meta-analysis. Hum Reprod Update 2007; 13: 343-355. [DOI:10.1093/humupd/dmm007]
14. Venetis C, Kolibianakis E, Bosdou J, Tarlatzis B. Progesterone elevation and probability of pregnancy after IVF: a systematic review and meta-analysis of over 60000 cycles. Hum Reprod Update 2013: dmt014. [DOI:10.1093/humupd/dmt014]
15. Mio Y, Sekijima A, Iwabe T, Onohara Y, Harada T, Terakawa N. Subtle rise in serum progesterone during the follicular phase as a predictor of the outcome of in vitro fertilization. Fertil Steril 1992; 58: 159-166. [DOI:10.1016/S0015-0282(16)55154-1]
16. Bustillo M, Stern JJ, Coulam CB. Serum progesterone at the time of human chorionic gonadotrophin does not predict pregnancy in in-vitro fertilization and embryo transfer. Hum Reprod 1995; 10: 2862-2867. [DOI:10.1093/oxfordjournals.humrep.a135808]
17. Murad N. Ultrasound or ultrasound and hormonal determinations for in vitro fertilization monitoring. Int J Gynecol Obstet 1998; 63: 271-276. [DOI:10.1016/S0020-7292(98)00111-8]
18. Kyrou D, Kolibianakis EM, Fatemi HM, Tarlatzis BC, Tournaye H, Devroey P. Is earlier administration of human chorionic gonadotropin (hCG) associated with the probability of pregnancy in cycles stimulated with recombinant follicle-stimulating hormone and gonadotropin-releasing hormone (GnRH) antagonists? A prospective randomized trial. Fertil Steril 2011; 96: 1112-1115. [DOI:10.1016/j.fertnstert.2011.08.029]
19. Hauzman E, Bodri D, Guillen J, Vidal R, Coll O, Vernaeve V. Exploring different criteria by 2D or 3D ultrasound for triggering final oocyte maturation in an oocyte donation program: a randomized pilot study. Hum Reprod 2011: 26 (suppl.): i95-i96.
20. Kolibianakis EM, Papanikolaou EG, Tournaye H, Camus M, Van Steirteghem AC, Devroey P. Triggering final oocyte maturation using different doses of human chorionic gonadotropin: a randomized pilot study in patients with polycystic ovary syndrome treated with gonadotropin-releasing hormone antagonists and recombinant follicle-stimulating hormone. Fertil Steril 2007; 88: 1382-1388. [DOI:10.1016/j.fertnstert.2006.12.058]
21. Tarlatzis B, Fauser B, Kolibianakis E, Diedrich K, Devroey P. GnRH antagonists in ovarian stimulation for IVF. Hum Reprod Update 2006; 12: 333-340. [DOI:10.1093/humupd/dml001]
22. Mochtar M, Custers I, Koks C, Bernardus R, Verhoeve H, Mol B, et al. Timing oocyte collection in GnRH agonists down-regulated IVF and ICSI cycles: a randomized clinical trial. Hum Reprod 2011; 26: 1091-1096. [DOI:10.1093/humrep/der048]
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
