International Journal of
Reproductive Biomedicine
Sat, Dec 21, 2024
[Archive]
Volume 16, Issue 1 (January 2018)
IJRM 2018, 16(1): 35-40 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Nasiri M, Jahangirizadeh K. Granulocyte colony-stimulating factor gene rs1042658 variant and susceptibility to idiopathic recurrent pregnancy loss: A case-control study. IJRM 2018; 16 (1) :35-40
URL: http://ijrm.ir/article-1-947-en.html
URL: http://ijrm.ir/article-1-947-en.html
1- Department of Biology, Islamic Azad University, Arsanjan Branch, Arsanjan, Iran , nasiri@iaua.ac.ir
2- Department of Biology, Islamic Azad University, Arsanjan Branch, Arsanjan, Iran
2- Department of Biology, Islamic Azad University, Arsanjan Branch, Arsanjan, Iran
Abstract: (2896 Views)
Background: Granulocyte colony-in stimulating factor (G-CSF) gene can be a potential candidate gene implicated recurrent pregnancy loss (RPL), a common complication of pregnancy with the prevalence of 1-5% among women of reproductive age.
Objective: To investigate the association between rs1042658 polymorphism in the 3' untranslated region (3'UTR) of G-CSF gene and the risk of unexplained RPL among Iranian women.
Materials and Methods: In total, 122 women with unexplained RPL and 140 healthy postmenopausal women as a control group were enrolled in this case-control study. Tetra-primer amplification refractory mutation system-polymerase chain reaction was performed to determine the rs1042658 genotypes in all subjects.
Results: Statistically significant differences were detected between the distribution frequencies of both heterozygote CT, and carriage of T allele (TT+CT) genotypes of the rs1042658 between case and control groups. Allelic association was not observed with RPL.
Conclusion: Regarding the results of the present study, G-CSF rs1042658 gene polymorphism could be considered as a probable risk factor for unexplained RPL among Iranian women.
Objective: To investigate the association between rs1042658 polymorphism in the 3' untranslated region (3'UTR) of G-CSF gene and the risk of unexplained RPL among Iranian women.
Materials and Methods: In total, 122 women with unexplained RPL and 140 healthy postmenopausal women as a control group were enrolled in this case-control study. Tetra-primer amplification refractory mutation system-polymerase chain reaction was performed to determine the rs1042658 genotypes in all subjects.
Results: Statistically significant differences were detected between the distribution frequencies of both heterozygote CT, and carriage of T allele (TT+CT) genotypes of the rs1042658 between case and control groups. Allelic association was not observed with RPL.
Conclusion: Regarding the results of the present study, G-CSF rs1042658 gene polymorphism could be considered as a probable risk factor for unexplained RPL among Iranian women.
Type of Study: Original Article |
References
1. Tay SS, Plain KM, Bishop GA. Role of IL-4 and Th2 responses in allograft rejection and tolerance. Curr Opin Organ Transplant 2009; 14: 16-22. [DOI:10.1097/MOT.0b013e32831ebdf5]
2. Rasti Z, Nasiri M. Association of the+ 49 A/G polymorphism of CTLA-4 gene with idiopathic recurrent spontaneous abortion in women in southwest of Iran. J Reprod Infertil 2016; 17: 151-156.
3. Martins A, Han J, Kim SO. The multifaceted effects of granulocyte colony-stimulating factor in immunomodulation and potential roles in intestinal immune homeostasis. IUBMB Life 2010; 62: 611-617. [DOI:10.1002/iub.361]
4. Root RK, Dale DC. Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor: comparisons and potential for use in the treatment of infections in nonneutropenic patients. J Infect Dis 1999; 179 (Suppl.): S342-352. [DOI:10.1086/513857]
5. Mannon PJ, Leon F, Fuss IJ, Walter BA, Begnami M, Quezado M, et al. Successful granulocyte-colony stimulating factor treatment of Crohn's disease is associated with the appearance of circulating interleukin-10-producing T cells and increased lamina propria plasmacytoid dendritic cells. Clin Exp Immunol 2009; 155: 447-456. [DOI:10.1111/j.1365-2249.2008.03799.x]
6. Boneberg EM, Hartung T. Granulocyte colony-stimulating factor attenuates LPS-stimulated IL-1β release via suppressed processing of proIL-1, whereas TNF-α release isinhibited on the level of proTNF-α formation. Eur J Immunol 2002; 32: 1717-1725.
https://doi.org/10.1002/1521-4141(200206)32:6<1717::AID-IMMU1717>3.0.CO;2-N [DOI:10.1002/1521-4141(200206)32:63.0.CO;2-N]
7. Brigham SA, Conlon C, Farquharson RG. A longitudinal study of pregnancy outcome following idiopathic recurrent miscarriage. Hum Reprod 1999; 14: 2868-2871. [DOI:10.1093/humrep/14.11.2868]
8. Halonen M, Lohman IC, Stern DA, Spangenberg A, Anderson D, Mobley S, et al. Th1/Th2 patterns and balance in cytokine production in the parents and infants of a large birth cohort. J Immunol 2009; 182: 3285-3293. [DOI:10.4049/jimmunol.0711996]
9. Saito S, Nakashima A, Shima T, Ito M. Th1/Th2/Th17 and regulatory T-cell paradigm in pregnancy. Am J Reprod Immunol 2010; 63: 601-610. [DOI:10.1111/j.1600-0897.2010.00852.x]
10. Cornish AL, Campbell IK, McKenzie BS, Chatfield S, Wicks IP. G-CSF and GM-CSF as therapeutic targets in rheumatoid arthritis. Nat Rev Rheumatol 2009; 5: 554-559. [DOI:10.1038/nrrheum.2009.178]
11. Vasiliu IM, Petri MA, Baer AN. Therapy with granulocyte colony-stimulating factor in systemic lupus erythematosus may be associated with severe flares. J Rheumatol 2006; 33: 1878-1880.
12. Rutella S, Zavala F, Danese S, Kared H, Leone G. Granulocyte colony-stimulating factor: A novel mediator of T cell tolerance. J Immunol 2005; 175: 7085-7091. [DOI:10.4049/jimmunol.175.11.7085]
13. Nasiri M, Rasti Z. CTLA-4 and IL-6 gene polymorphisms: risk factors for recurrent pregnancy loss. Hum Immunol 2016; 77: 1271-1274. [DOI:10.1016/j.humimm.2016.07.236]
14. Davari-tanha F, Shahrokh Tehraninejad E, Ghazi M, Shahraki Z. The role of G-CSF in recurrent implantation failure: A randomized double blind placebo control trial. Int J Reprod Biomed 2016; 14: 737-742. [DOI:10.29252/ijrm.14.12.737]
15. Cavalcante MB, Costa Fda S, Barini R, Araujo Júnio E. Granulocyte colony-stimulating factor and reproductive medicine: A review. Iran J Reprod Med 2015; 13: 195-202.
16. Barad DH, Yu Y, Kushnir VA, Shohat-Tal A, Lazzaroni E, Lee HJ, et al. A randomized clinical trial of endometrial perfusion with granulocyte colony-stimulating factor in in vitro fertilization cycles: impact on endometrial thickness and clinical pregnancy rates. Fertil Steril 2014; 101: 710–715 [DOI:10.1016/j.fertnstert.2013.12.016]
17. Rahmati M, Petitbarat M, Dubanchet S, Bensussan A, Chaouat G, Ledee N. Granulocyte-colony stimulating factor related pathways tested on an endometrial ex-vivo model. PLoS One 2014; 9: e102286. [DOI:10.1371/journal.pone.0102286]
18. Würfel W, Santjohanser C, Hirv K, Bühl M, Meri O, Laubert I, et al. High pregnancy rates with administration of granulocyte colony-stimulating factor in ART-patients with repetitive implantation failure and lacking killer-cell immunoglobulin-like receptors. Hum Reprod 2010; 25: 2151-2152. [DOI:10.1093/humrep/deq106]
19. Boneberg EM, Hartung T. Molecular aspects of anti-inflammatory action of G-CSF. Inflamm Res 2002; 51: 119-128. [DOI:10.1007/PL00000283]
20. Arpinati M, Green CL, Heimfeld S, Heuser JE, Anasetti C. Granulocyte-colony stimulating factor mobilizes T helper 2-inducing dendritic cells. Blood 2000; 95: 2484-2490. Nasiri et al
21. Veenstra van Nieuwenhoven AL, Heineman MJ, Faas MM. The immunology of successful pregnancy. Hum Reprod Update 2003; 9: 347-357. [DOI:10.1093/humupd/dmg026]
22. Singh RP, Hasan S, Sharma S, Nagra S, Yamaguchi DT, Wong DT, et al. Th17 cells in inflammation and autoimmunity. Autoimmun Rev 2014; 13: 1174-1181. [DOI:10.1016/j.autrev.2014.08.019]
23. Martins AJ, Colquhoun P, Reid G, Kim SO. Reduced expression of basal and probiotic-inducible G-CSF in intestinal mononuclear cells is associated with inflammatory bowel disease. Inflamm Bowel Dis 2009; 15: 515-525. [DOI:10.1002/ibd.20808]
24. Santner-Nanan B, Peek MJ, Khanam R, Richarts L, Zhu E, Fazekas de St Groth B, et al. Systemic increase in the ratio between Foxp3+ and IL-17-producing CD4+ T cells in healthy pregnancy but not in preeclampsia. J Immunol 2009; 183: 7023-7030. [DOI:10.4049/jimmunol.0901154]
25. Sharma S. Natural killer cells and regulatory T cells in early pregnancy loss. Int J Dev Biol 2014; 58: 219-229. [DOI:10.1387/ijdb.140109ss]
26. Jin LP, Chen QY, Zhang T, Guo PF, Li DJ. The CD4+CD25 bright regulatory T cells and CTLA-4 expression in peripheral and decidual lymphocytes are down-regulated in human miscarriage. Clin Immunol 2009; 133: 402-410. [DOI:10.1016/j.clim.2009.08.009]
27. Scarpellini F, Sbracia M. Use of granulocyte colony-stimulating factor for the treatment of unexplained recurrent miscarriage: a randomised controlled trial. Hum Reprod 2009; 24: 2703-2708. [DOI:10.1093/humrep/dep240]
28. Santjohanser C, Knieper C, Franz C, Hirv K, Meri O, Schleyer M, et al. Granulocyte-colony stimulating factor as treatment option in patients with recurrent miscarriage. Arch Immunol Ther Exp (Warsz) 2013; 61: 159-164. [DOI:10.1007/s00005-012-0212-z]
29. Morris ES, MacDonald KP, Rowe V, Johnson DH, Banovic T, Clouston AD, et al. Donor treatment with pegylated G-CSF augments the generation of IL-10-producing regulatory T cells and promotes transplantation tolerance. Blood 2004; 103: 3573-3581. [DOI:10.1182/blood-2003-08-2864]
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
