دوره 14، شماره 4 - ( 1-1395 )                   جلد 14 شماره 4 صفحات 240-231 | برگشت به فهرست نسخه ها

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Sabeti P, Pourmasumi S, Rahiminia T, Akyash F, Talebi A R. Etiologies of sperm oxidative stress. IJRM 2016; 14 (4) :231-240
URL: http://ijrm.ir/article-1-745-fa.html
ثابتی پروین، پورمعصومی سهیلا، رحیمی نیا طاهره، اکیاش فاطمه، طالبی علیرضا. اتیولوژی استرس اکسیداتیو بر اسپرم. International Journal of Reproductive BioMedicine. 1395; 14 (4) :231-240

URL: http://ijrm.ir/article-1-745-fa.html

اتیولوژی استرس اکسیداتیو بر اسپرم
پروین ثابتی1 ، سهیلا پورمعصومی1 ، طاهره رحیمی نیا1 ، فاطمه اکیاش1 ، علیرضا طالبی* 2
1- مرکز تحقیقاتی و درمانی ناباروری، دانشگاه علوم پزشکی شهید صدوقی، یزد ،ایران
2- مرکز تحقیقاتی و درمانی ناباروری، دانشگاه علوم پزشکی شهید صدوقی، یزد ،ایران ، prof_talebi@ssu.ac.ir
چکیده:   (3897 مشاهده)
اسپرم در مراحل مختلف اسپرماتوژنز نسبت به گونه­های فعال اکسیژن (ROS) آسییب پذیر است. با این حال، سطح ROS سیمن توسط آنتی اکسیدان­ها که اثرات مفیدی بر روی پارامترها و پتانسیل باروری اسپرم دارند، کنترل شده است. میتوکندری و غشای پلاسمایی اسپرم دو محل اصلی تولید ROS در این    سلول­ها می باشند. علاوه بر این، لکوسیت­ها شامل پلی­مورفونوکلوئرها (PMN) و ماکروفاژها، تولید دسته گسترده ای از مولکول­های اکسیژن از جمله    رادیکال­های آزاد، گونه­های غیررادیکال و گونه­های نیتروژن فعال را به عهده دارند. نقش فیزیولوژیکیROS ، افزایش cAMP داخل سلولی و پس از آن    فعال­سازی پروتئین کیناز در سیستم تناسلی مرد است که نشان می­دهد اسپرم به مقدار کمی ازROS ، برای به دست آوردن توانایی و تنظیم بلوغ و تراکم هسته­ای جهت بارور نمودن تخمک نیاز دارد. عوامل درونی و بیرونی متعددی است که می­تواند در تعامل با لیپیدها و پروتئین به ایجاد استرس اکسیداتیو و تولید ROS بیانجامد که نتیجه آن، پراکسیداسیون لیپیدی، قطعه قطعه شدن  DNA، آسیب آکسونم، دناتوره شدن آنزیم­ها، افزایش یون سوپراکساید در میتوکندری، کاهش فعالیت آنتی اکسیدانی و در نهایت اختلال در روند اسپرماتوژنز خواهد بود. به طور کلی علل تولید استرس اکسیداتیو شامل طیف گسترده ای از عوامل بالینی و زیست محیطی می­باشد. اگر استرس اکسیداتیو به عنوان عامل اصلی آسیب به DNA در اسپرم پذیرفته شود، پس باید دلیل خوبی برای درمان آنتی اکسیدانی در این شرایط وجود داشته باشد.
واژه‌های کلیدی: اسپرم، استرس اکسیداتیو، رادیکال ازاد اکسیژن.
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نوع مطالعه: Original Article |
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