Volume 15, Issue 1 (1-2017)                   IJRM 2017, 15(1): 41-48 | Back to browse issues page

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Ostovan F, Gol A, Javadi A. Investigating the effects of Citrullus colocynthis pulp on oxidative stress in testes and epididymis in streptozotocin-induced diabetic male rats. IJRM 2017; 15 (1) :41-48
URL: http://ijrm.ir/article-1-788-en.html
Investigating the effects of Citrullus colocynthis pulp on oxidative stress in testes and epididymis in streptozotocin-induced diabetic male rats
Fereshteh Ostovan1 , Ali Gol * 2, Abdolreza Javadi3
1- Faculty of Science, Payam noor University, Iranshhar, Iran.
2- Department of Biology, Faculty of Science, University of Shahid Bahonar, Kerman, Iran. , agol@mail.uk.ac.ir
3- Pathology Department, Beheshti University of Medical Sciences, Tehran, Iran.
Abstract:   (3490 Views)
Background: Diabetes mellitus (DM) is one of the most common metabolic diseases in humans, affecting 100 million people around the world.
Objective: Investigating the effects of Citrullus colocynthis pulp on oxidant and antioxidant factors of testes and epididymis in streptozotocin-induced diabetic male rats.
Materials and Methods: Thirty-two male rats were divided into four groups eight each: 1) N (normal) group, 2) N+C group, 3) D (diabetic) group and 4) D+C group. Groups N and D received normal saline 2 ml orally for two weeks and groups N+C and D+C received 10 mg/kg.bw Citrullus colocynthis pulp orally for two weeks. Diabetes was induced by single intraperitoneal injection of streptozotocin (STZ) at 65 mg/kg.
Results: D group had a significant increase in H2O2 (Hydrogen peroxide) and MDA (malondialdehyde) concentrations, and CAT (catalase) activity, and also a significant decrease in Peroxidase (POD) activity compared to N group. D+C group had a significant decrease in H2O2 and MDA concentrations and, CAT activity and significant increase in POD activity compared to D group.
Conclusion: Citrullus colocynthis pulp in two weeks had beneficial effects on oxidants and antioxidants changes in reproductive system in streptozotocin-induced diabetic rats.
Keywords: Diabetes, Catalase, Peroxidase, Malondialdehyde, Hydrogen peroxide, Oxidant.
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Type of Study: Original Article |
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